B3log Solo 登录

mulin

Play with informatics on chemistry and biology -- Make It Happen
浏览次数: 350,172    文章总数: 10    评论总数: -1

Variants representation, annotation and prioritization in post-GWAS era 有更新!

I am so happy to introduce a comprehensive web framework for Variants representation, annotation and prioritization in post-GWAS era.  The framework expressed satisfactory convenience and performance for post-GWAS analysis. Using a one-stop solution, users can quickly fetch very comprehensive annotation when they are browsing the GWAS result in highly interactive Circos-style graph or dynamic Manhattan panel. System can perform independent variant prioritization based on additive effect principle by combining the original statistical value and variant prioritization score.

Please visit the web site from http://jjwanglab.org/gwasrap

发件人 gwas

2011北京GTC CUDA大会关于生物信息学遗传计算方面的总结 有更新!

参加了2011北京GTC CUDA大会,一下是关于生物信息学遗传计算方面的总结。

国内外个性化检测公司对比 有更新!

 

国外

国内

区域

欧洲,北美

一线城市

检测技术

芯片,单位点验证平台

单位点检测

应用范畴

疾病风险,个性化用药,亲缘关系,咨询

疾病风险,个性化用药,发展潜能

检测标准

标准化采样,提取,检测,QA

检测标准未知

产品种类

单一

复杂,混乱

平台技术

丰富的用户管理,数据展现,跟踪,交流平台

简单的网页

价格

单一产品线定价

价格无法琢磨

一个关于个性化检测 (personal genomics) 的调查 有更新!

个性化检测这个东西随着GWAS的发展越来越走向大众,在国外23andme和decodeme等公司漂亮的把个性化检测拉近普通人的生活。目前还没有发现国内有专业的个性化检测公司, 虽然基因检测的招牌在国内喊了很多年,但是国内基因检测市场的混乱实在让人不敢恭维。偶然发现了一个搞个性化检测人群调查的东西,感觉可以通过它来看看国内对这方面的市场需求。

 

GWASdb: a database for human genetic variants identified by genome wide association studies 有更新!

we are releasing a one stop shop which combines collections of GVs from GWAS and their comprehensive functional annotations, as well as disease classifications. We aim to help researchers and clinicians to maximize the utilility of the most recent GWAS data and gain biological insights through an integrative, multi-dimensional functional annotation portal. The database provides following functions:

(i) in addition to all the GVs annotated in the NHGRI GWAS Catalog, we manually curated the GVs that are marginally significant (P value < 10-3) by looking into the supplementary materials of each original publication.

(ii) we provide extensive functional annotations for these the GVs.

(iii) furthermore, we manually classified these GVs into diseases according to Dolite and HPO for easy access. Therefore, the database can also conduct gene-based pathway enrichment and PPI network association analysis for the diseases with sufficient variants.

Please visit the site: jjwanglab.org/gwasdb

GWAS catalog for publication curation 有更新!

The bioinformatics lab I engaged will release a comprehensive database about GWAS data to integrate genomic variants. Here is the plot about TOP 2 trait/disease associated SNPs in each published GWAS papers.

Cheung Chau Island Hiking 有更新!

长洲岛形状是个“人”字,我们的时间安排是上午徒步玩“捺”,下午骑车玩“撇”,这样不至于太累。

图中上方的点是码头,右边的点是上午要去的地方,左边的点是下午先去的地方。如果有时间再去长洲岛的北部。


在較大的地圖上查看Route

仙剑奇侠传5 普通手柄配置 有更新!

仙剑奇侠传5发售了,但是仍然不支持手柄。但是用JoyToKey可以比较完美的实现,以下操作步骤。主要针对的是普通的类似PS2, PS3的手柄,需要有摇杆。

1. 首先去JoyToKey官方网站下载最新版的软件,http://joytokey.webs.com/。 或者直接点击这里下载

2. 先解压软件。

3. 连接手柄,测试连接。

4. 下载我的配置文件,点击这里。将这个配置文件拷贝到JoyToKey的根目录下。 打开JoyToKey程序应该可以看到左边列表中有一个Pal5。

5. 创建与游戏的映射,具体步骤: 点击菜单栏的->配置(Configration)->连接配置文件到程序(Associate config files with applications)->添加(Add)->输入游戏名字,路径(记住是你仙剑5安装路径下的Pal5.exe)->选择游戏对应的配置文件(Associated config file)Pal5->确定(OK)。

6. 进入游戏调试。

 

Periodical Work Reprot 有更新!

Here list the periodical working report

  • GATK framework

生物信息学近期学术文章--定时更新(Periodical Bioinformatics Publication) 有更新!

Here is the Periodical Bioinformatics Publication, most of the sources target the jounals of Bioinformatics, BMC Bioinformatics, Briefings in Bioinformatics, PLOS Computational Biology, Computers in Biology and Medicine, Journal of Bioinformatics and Computational Biology, IEEE/ACM Transactions on Computational Biology and Bioinformatics, Computer Methods and Programs in Biomedicine, etc.

We can easily get the latest academic news from this article. Just go to this article to see details!